Doubling as a track star, Goodwin is a speedy yet raw prospect who was drafted in the third round, 78th overall, out of Texas. The Bills also signed fourth-round pick, defensive back Duke Williams; fifth-round pick, defensive back Jonathan Meeks; and sixth-round pick, kicker Dustin Hopkins.
The signings were announced Friday morning, hours before the Bills were set to open a three-day rookie camp.
Buffalo has now signed five of the eight players it drafted two weeks ago.
The Bills have yet to sign their top three selections, including first-round pick, quarterback EJ Manuel.