The Catalan club says Pique will rest as "precaution due to pain in his right ankle," while Puyol won't play because of pain in his right knee.
Barcelona is on a poor run in the domestic competition and enters round 28 in third place, trailing Real Madrid by four points before the leader visits Malaga on Saturday.
Barcelona visits Madrid in a critical "clasico" match next Sunday.
- Sports & Recreation
- Gerard Pique
- Carles Puyol
- BARCELONA, Spain
- Javier Mascherano