Puyol came on as a substitute during his side's emphatic comeback victory against AC Milan on Tuesday evening, but after complaining of discomfort, Spain coach Vicente Del Bosque decided not to include him in his squad for the upcoming World Cup 2014 qualifiers with France and Finland.
It is not the first time the center back's right knee has caused him problems, with the 33-year-old also sidelined last May with a similar problem.
Puyol recently signed a new three-year deal at Camp Nou.
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- Vicente Del Bosque
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