The Spain goalkeeper is set to leave the club at the end of the season and, after being diagnosed with a torn ACL, he has played his last game in a Barcelona shirt.
There was a further worry for coach Gerardo Martino when Andres Iniesta was withdrawn at halftime as a precaution with a nagging thigh problem.
Yet, three days after Sunday's epic Clasico victory, a routine win at Camp Nou at least allowed Barca to apply further pressure to La Liga title rivals Atletico and Real Madrid. Two goals from Neymar and one from Lionel Messi proved enough to see off a Celta side coached by Barca legend Luis Enrique.
The visitors threatened sporadically, most notably just after halftime when Valdes' replacement Jose Pinto made an excellent double save to deny Augusto Fernandez and Santi Mina.
Celta was already two down by that stage, however, Neymar having finished off a trademark flowing move from Barca with a simple tap-in, before Messi ran onto Iniesta's pass and beat Yoel for his 22nd league goal of the season.
Neymar, who had come in for criticism following his performance against Real, added his second and Barcelona's third in the 67th minute, allowing the Catalan giants to celebrate their 1,000th La Liga match at Camp Nou in style.
Neymar's opener came inside six minutes as he tapped into an empty net after incisive approach play involving Iniesta, Messi and Alexis Sanchez.
The Brazilian ought to have doubled his tally nine minutes later, firing into the side netting from a tight angle after being picked out by Messi, who was then denied by Yoel after breaking in behind the Celta back line once again.
The hosts suffered a setback midway through the half when Valdes had to be carried off on a stretcher.
Adriano was penalized for a handball close to the edge of the area and, after appearing to originally award a penalty, referee Miguel Ayza gave a free kick, from which the keeper fell awkwardly on his right knee while making a routine save.
Despite a lengthy stoppage, Barca's rhythm was not disrupted as Messi doubled the advantage on the half-hour, latching onto Iniesta's pinpoint pass before rounding Yoel and slotting in.
Seven minutes into the second half, Pinto made a superb double stop, first keeping out Fernandez's close-range prod before jumping to his feet to parry away Mina's powerful rebound.
Neymar then put the result beyond doubt, picking up Sanchez's raking pass before firing beyond Yoel low into the bottom right-hand corner.
Sanchez shot wide 18 minutes from time after being picked out by substitute Pedro but it mattered little as Barca comfortably saw out the victory.
- Sports & Recreation
- Victor Valdes
- Andres Iniesta
- Lionel Messi