Pettitte will try to help the Yankees finish 8-2 on their homestand while earning his 249th career win Sunday.
Oakland (17-14) had scored 38 runs while batting .272 in its six games before a 4-2 loss at Yankee Stadium on Saturday. After collecting 10 hits in a 2-0 win in Friday's series opener, the A's had four through eight scoreless innings Saturday before getting two in a two-run ninth.
The six hits were the fewest for Oakland since it had three in a 3-0 loss to Baltimore on April 26.
"That's the name of the game, getting hot all together," catcher John Jaso told the team's website. "Get a walk or two in there and a hit. We didn't really do that much."
Lyle Overbay, meanwhile, boosted the injury-plagued Yankees with his third home run in six games. The last three hitters for New York (18-11) were a combined 4 for 9 with two solo homers.
"The bottom of the lineup was excellent. Just an outstanding performance by those guys," manager Joe Girardi said of Overbay, Eduardo Nunez and Chris Stewart.
In his first start against the A's in nearly four years, Pettitte (3-2, 3.86 ERA) will try to rebound from a 9-1 loss to Houston on Monday. After posting a 2.22 ERA in his first four starts, the veteran left-hander gave up seven runs and 10 hits in 4 1-3 innings against his former club.
Pettitte hadn't allowed that many hits since giving up 10 to Boston in a 10-8 loss on Sept. 24, 2010. He also yielded seven runs for the first time since that game.
"All around just a sickening game for me, and a very frustrating game. I'm just looking forward to getting back out there," he said.
Pettitte, who hasn't faced Oakland since July 25, 2009, is 12-7 with a 3.32 ERA in 24 career matchups, including three in the playoffs. He earned his first major league win against the A's on June 7, 1995, and is 7-4 with a 3.02 ERA in 12 home starts against them in his two stints with New York.
The 40-year-old Pettitte will pitch opposite 24-year-old Dan Straily, who is trying to rebound from a miserable effort of his own in his first start against the Yankees. After being called up from the minors for the second time this season, Straily (1-0, 6.35) gave up a career-high six runs over 4 2-3 innings to the Los Angeles Angels on Monday, but he avoided the loss as Oakland rallied late in a 10-8 win in 19 innings.
Vernon Wells is the only Yankees player to have faced Straily, and he hit a two-run homer off the right-hander in a 6-5 loss for the Angels on Sept. 11. Jed Lowrie is the A's only active player to have hit against Pettitte, going 4 for 10 with a home run.
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