Oakland seeks an 18th victory in 21 games while trying to remain unbeaten against the White Sox this season Friday night.
Chicago manager Robin Ventura won't be on the bench until Saturday as he attends his daughter's graduation, and bench coach Mark Parent, who led the team Thursday, will give way to pitching coach Don Cooper on Friday as Parent attends his son's graduation.
''It feels really special,'' Chicago native Rosales said after the A's hit a season-high four home runs. ''I had family in the stands and a lot of friends. I grew up a Cubs fan, I grew up coming here when it was Comiskey (Park). Just to play on this field is a great opportunity, and to do that is just unbelievable to me.''
Oakland, which has outscored opponents 96-51 while winning 17 of 20, has taken all four matchups with the White Sox after sweeping a three-game series last weekend.
''The guys have just been awesome, they've been playing really well, a great team chemistry, guys coming up big and getting big hits and pitchers keeping us in the ballgame,'' Rosales said. ''It's been a great start to the season.''
The last-place White Sox (25-33), in contrast, continue to struggle. They beat Seattle 7-5 in 16 innings Wednesday to end their eight-game losing streak but blew a three-run lead Thursday.
Alejandro De Aza had three hits and Alexei Ramirez drove in two runs for Chicago, which had won six of its previous eight at home.
''We need to start winning some games or we might be saying bye to some people in July,'' second baseman Gordon Beckham said. ''Hopefully, we can start winning and get a streak going.''
The White Sox will turn to Chris Sale, who continues to be one of their few bright spots.
Sale (5-3, 2.44 ERA) gave up one run and four hits in six innings but suffered a 2-0 loss to Oakland on Sunday. He's allowed two or fewer earned runs in seven straight outings, posting a 1.41 ERA in that stretch.
His 28-inning scoreless streak came to an end when Josh Donaldson hit a sacrifice fly in the sixth.
''I'm glad it's over so we can stop talking about it and get back to normal baseball business,'' Sale said. "'I just flat out got outpitched by (Jarrod) Parker."
The two hurlers will oppose each other again, as Parker (4-6, 4.90) looks to stay hot after giving up two hits and striking out seven in 6 1-3 innings to beat the White Sox.
The right-hander is 2-1 with a 1.98 ERA over his last four starts, pitching at least six-plus innings in each.
''It makes our jobs a lot easier," closer Grant Balfour said. "Parker's been on a little roll here now.''
In his only appearance against the White Sox, Parker allowed one run in 6 1-3 innings of a 5-4 victory April 25, 2012.
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