While Anderson looks to avoid a third straight rough start, Lester tries to remain undefeated in Wednesday's series finale.
After Oakland (13-8) scored four runs while being swept in a three-game set at Tampa Bay and lost 9-6 at Boston on Monday, Seth Smith homered and Bartolo Colon pitched seven solid innings during a rain-shortened, 13-0, seven-inning rout Tuesday.
The A's took advantage of eight walks, two balks and two errors by the Red Sox (13-7) to post a much-needed victory. John Jaso and Brandon Moss each had three hits with two RBIs for Oakland, which has scored a major league-leading 119 runs.
Boston, meanwhile, has dropped three of four after it won seven in a row.
"The weather conditions weren't ideal, but to say that it was a major distraction, I don't know that we can go that far. We see what Bartolo did against us," Red Sox manager John Farrell said.
Former Boston outfielder Coco Crisp added two hits with two RBIs after going 1 for 10 in three contests following a 12-game hitting streak.
Looking for a 10th win in 11 games versus Boston, the A's will try to get the best of Lester (3-0, 1.73 ERA).
The left-hander has not allowed a homer and struck out 23 in 26 innings in four starts. He gave up two runs and four hits in seven innings of a 6-3 win at Cleveland on Thursday.
"Lester has a lot of ways to attack hitters," his former manager and current Cleveland skipper Terry Francona told the Red Sox's official website. "Whether it's depth on his two-seamer or life on the fastball, and then he's got that cutter. And he threw an occasional breaking ball. He has a lot of ways of opening up the plate."
Lester is 3-3 with a 4.15 ERA in 10 starts versus Oakland, which hopes Anderson (1-3, 5.95) can get back on track after two straight rough outings and improve on his 5-2 mark and 2.70 ERA in eight starts against the Red Sox.
The left-hander yielded two runs in each of his first two starts but allowed 11 and walked five while striking out three in 6 2-3 innings to lose his last two. He gave up four runs in the first inning of an 8-3 loss at Tampa Bay on Friday before leaving with a sprained ankle.
Anderson, however, appears healthy to return to the mound Wednesday.
"I can obviously feel it a little bit when running," Anderson told the Athletics' official website. "Other than that, it feels good."
Batting .308 (4 for 13) with a double against Anderson, David Ortiz had one of Boston's three hits off Colon. Ortiz is 6 for 12 in three games since starting the season on the disabled list with an Achilles injury.
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