The Highlanders (13-6, 3-1 Big South) were at the free-throw line inside the game's first minute, hitting 25 of 28, and led by as many as 14 before halftime.
Longwood (5-14, 0-4) cut the lead to single digits several time, coming as close as 51-49 on a 7-0 run early in the second half, but it seemed Radford had an answer each time. All five Highlanders starters scored in double figures - Brandon Holcomb with 14, R.J. Price 13 and Kyle Noreen 10.
Price and Anderson each hit three 3-pointers and Radford shot 49.2 percent from the field (31-63).
Tristan Carey led the Lancers with 27 points - going 5-for-9 from 3-point range - and Lucas Woodhouse added 17 points with 12 assists.
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