Chris Jones contributed 14 points and Keith Coleman 10 for the Mean Green (5-3).
Onochie Ochie led the Lions (3-3) with 15 points with JaMichael Hawkins adding 14 and Devonte Upson 12.
North Texas took a 41-27 lead at halftime on the strength of 50 percent shooting.
Though their shooting prowess tailed off a little in the second half, the Mean Green were up by 18 at one point and never allowed the Lions to get within single digits. Southeast Louisiana shot only 34.4 percent for the game, including just 3 of 16 from 3-point range.
North Texas had a 45-37 edge on the boards with Colin Voss grabbing 12 rebounds. Jordan Williams' double-double was the first of the junior's career.
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