The match-up was announced by the Las Vegas Review-Journal on Thursday evening.
Both fighters come into the bout on losing streaks. Overeem has lost both of his fights since returning from a de facto nine-month drug suspension, while Mir, who replaced Overeem in the title fight after he was suspended, has now lost three in a row.
UFC 167 will be headlined by a welterweight title fight between Georges St-Pierre and Johny Hendricks. Rashad Evans vs. Chael Sonnen, Rory MacDonald vs. Robbie Lawler and Josh Koscheck vs. Tyron Woodley rounds out the pay-per-view portion of the card.
UFC 167 also servers as the UFC's 20th Anniversary event.
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