San Francisco used the same five starting offensive linemen for the previous 29 games.
Iupati is out Monday night against the Redskins after spraining a ligament in his left knee a week ago. It's the only start he's missed since entering the NFL in 2010.
The 49ers' defense is without cornerback Tarell Brown, inactive with a rib injury.
Redskins fullback Darrel Young is inactive because of a hamstring injury, and defensive lineman Stephen Bowen is out with a hurt left knee. Starting tight end Jordan Reed is out with a concussion, so Fred Davis is active for the first time since Washington's fifth game.
AP NFL website: www.pro32.ap.org
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