Asia Taylor added 13 points for the Cardinals (22-8), who will face No. 18 St. John’s in the quarterfinals on Sunday.
Leading 38-33 early in the second half, Louisville went on a 22-8 run over the next 13 minutes to take control. Taylor got the burst started with back-to-back layups. Then Shawnta’ Dyer took over scoring seven of her nine points during the spurt. Bria Smith capped the run with a 3-pointer that made it 60-41 with 3:53 left.
A back and forth first half saw Villanova take a 29-26. After the Wildcats committed a foul with 2.9 seconds left, Schimmel hit a 3-pointer at the buzzer to tie the game at 29.
Laura Sweeney had 13 points and 10 rebounds to lead Villanova.