Lucas led a balanced attack for the Nittany Lions (11-3, 1-1 Big Ten) with Nikki Greene adding 14 points and Mia Nickson with 10 points and 14 rebounds.
Taylor Wurtz led Wisconsin (4-10, 0-2) with 17 points.
After Wisconsin pulled ahead 15-13 on back-to-back fastbreak layups, Penn State reeled off 14 straight points to take control.
Wisconsin cut the lead to seven, but the Nittany Lions finished the half on an 11-3 run and led 40-25 at the break.
The rout was on in the second half as the Badgers struggled offensively, shooting 33 percent for the game, including 2 of 18 from 3-point range.