Gonzaga (6-1) scored the game’s first 19 points and was up 40-8 with less than six minutes left in the first half. The Bulldogs led 53-13 at the break.
Gonzaga held Portland State’s leading scorer, Kate Lanz, to just 2 points. The Vikings (2-4) shot just 32.8 percent from the field, committed 26 turnovers and were outrebounded 56-33.
Jazmine Redmon scored 13 points, Lindsay Sherbert had 11 and Sonja Greinacher added 10 as Gonzaga had five players score in double figures.
It was the Bulldogs’ fourth straight win after losing to then-No. 11 Oklahoma on Nov. 14.
Angela Misa led Portland State with 15 points and 12 rebounds.