Lindsey Moore had 13 points and six assists, and Emily Cady had eight rebounds and six assists for the Huskers (23-7), the second seed in the tournament.
Hooper also grabbed seven rebounds to help Nebraska take a 44-30 advantage on the boards. The Huskers shot 46 percent from the field while the Hawkeyes shot 38 percent.
Theairra Taylor scored 22 points to lead Iowa (20-12). Melissa Dixon scored 18 points for the Hawkeyes.
Rachel Theriot’s 3-pointer just before halftime gave Nebraska a 34-24 lead, and the Huskers led by as many as 27 points in the second half.