Yolanda Richardson made 7 of 9 from the field and grabbed a game-high 16 rebounds to help Toledo (27-2, 15-1), the MAC regular-season champions, win its 15th straight game.
After Toledo went ahead 10-0, Brandy Woody’s jumper capped a 10-0 run for Ball State to tie it with 12:03 left in the half.
The Rockets closed out the period on 26-4 run to take a 36-14 lead into halftime. Shafir, a MAC Player of Year candidate, sparked the run with a 3-pointer.
Toledo led by as many as 31 points in the second half.
Nathalie Fontaine had 18 points to lead the Cardinals (15-14, 12-4). The loss snapped a four game winning streak for Ball State.