KK Houser and April Wilson scored 12 points apiece for the Boilermakers (18-3, 7-1 Big Ten). Taylor Manuel added 11 points for Purdue, which held a 45-30 rebounding edge.
Linda Rubene scored 13 points and Aulani Sinclair scored 11 for Indiana (10-11, 1-7). Rubene and Sinclair each had a team-high six rebounds. The Hoosiers have dropped six straight.
The Boilermakers never trailed and opened up a quick 12-2 lead, but Indiana tied the game three times late in the first half, the last at 26 before Purdue scored the last six points of the half.
Purdue holds a 50-25 edge in the all-time series.