Brittany Hrynko had 21 points and seven assists for the Blue Demons (12-3), who have won six in a row.
Louisville (12-3), which had won its previous three games, trailed 80-70 before Shoni Schimmel hit two 3-pointers. Monique Reid’s layup drew the Cardinals within 80-78, but they came no closer. Martin made a layup and Hrynko hit four free throws for DePaul.
Jasmine Penny had 15 points on 6-of-6 shooting and Katherine Harry grabbed 13 rebounds for the Blue Demons.
Reid led the Cardinals with 25 points. Schimmel scored 19, Antonita Slaughter scored 14 points and Bria Smith had 11 points and nine rebounds for Louisville.