Kresl was 5 of 5 from 3-point range, tying a school record for most 3-point attempts without a miss.
Arielle Roberson scored 18 points, and Chucky Jeffery had 11 points, eight assists and eight rebounds. Jen Reese added 10 points.
Colorado never trailed. Colorado led 39-21 at halftime and went on a 21-4 run to open the second half.
Colorado shot 50.8 percent from the field for the game, while New Mexico shot 30 percent. New Mexico had 23 turnovers.
Antiesha Brown led New Mexico (8-5) with 10 points, and Jourdan Erskine had seven rebounds.
This was Coach Linda Lappe’s career 100th win and her 50th in three years with Colorado.