The Cardinals (11-2), who led 47-12 at the half, shot 60.9 percent from the floor (39 of 64), with Deines going 8 for 10.
Although Louisville surpassed 90 points on four occasions earlier this season, this was the Cardinals’ first 100-point game and marked their second-largest margin of victory behind a 109-29 win over Coastal Carolina on Dec. 18, 1996.
Louisville had 22 steals, led by Jude Schimmel with eight, and forced 31 turnovers.
Schimmel also scored 15 points. Sara Hammond chipped in 14, Bria Smith 13, Cortnee Walton 12, Sheronne Vails 11 and Antonita Slaughter and Shoni Schimmel had 10 apiece.
Jordyn Peck, with 15 points off the bench, led the Seahawks (1-8), who shot 24.5 percent (12 of 49) from the field.