Jasmine Lister added 15 points and Christina Foggie had 11 for the Commodores (13-2, 1-1), who bounced back from a Southeastern Conference-opening loss at South Carolina on Thursday.
Nikki Byrd, the league’s leading rebounder, had 15 points and 13 rebounds for Mississippi (10-6, 0-3). Valencia McFarland chipped in with 10 points including two 3-pointers for the Rebels, playing their first SEC road game.
Clarke scored seven of Vanderbilt’s first nine points to open the second half, and Foggie had seven straight points in an 11-0 run, including her only 3-pointer, that put Vanderbilt up 45-33. Byrd sat out with her fourth foul for almost 2 minutes during Foggie’s 7-0 streak.