Sam Ostarello added 13 points and eight rebounds, Brittany Rayburn had 11 points and four assists, and Antionette Howard added 10 points and nine rebounds for the Boilermakers (10-3) in their final nonconference game.
Stephanie Rosado scored nine points to lead IPFW (4-8).
The Mastodons shot 23 percent from the field and made just 5 of 23 3-pointers, while committing 22 turnovers.
Purdue shot 46 percent from the field and outrebounded IPFW 40-32.
The Boilermakers open Big Ten play on Dec. 30 at home against Minnesota.