Monique Reid returned from a back injury to lead Louisville (3-1) with 18 points on 7-of-10 shooting. Becky Burke added 15, and Bria Smith had 13. Shoni Schimmel was the fourth Cardinal in double figures with 10 points and nine assists, while Ciera Warren scored eight and had 11 rebounds.
Freshman Kristen Stainback paced the Governors (2-1) with 15 points and was 4 of 8 on three-point attempts. Whitney Hanley added 12 points and six rebounds.
Stainback hit a three from the top of the key with 16:45 left in the second half to tie the game at 36. But Louisville answered 15 seconds later with a Burke three, sparking a 24-9 run during the next six minutes as the Cardinals slowly pulled away.