The Crimson (7-1, 4-1) scored 35 points in the second quarter in their most lopsided win over an Ivy rival since beating Cornell 77-0 in 1890. The margin was their largest since a 69-0 drubbing of Coast Guard in 1946.
The Lions (2-6, 1-4), who clinched their 38th losing season in 41 years, suffered their biggest loss since a 69-0 defeat against Rutgers in 1978 and gave up their most points since a 77-28 loss to Holy Cross in 1983.
After Harvard led 14-0 early in the second quarter, three consecutive Columbia turnovers led to Crimson touchdowns.
The victory was the 127th at Harvard for coach Tim Murphy, tying former Dartmouth coach Bob Blackman for third in Ivy play since the league was formed in 1956.