Robbie Rouse ran for 91 yards on 20 carries for the Bulldogs (5-3, 3-1 Mountain West). He became the first player in school history to surpass 4,000 yards rushing in a career.
Brett Smith threw two touchdown passes for the Cowboys (1-6, 0-3), but completed just 18 of 38 passes for 158 yards. He was intercepted by Phillip Thomas, who returned it for a TD—the fifth time Fresno State has done that this season, a school record.
Carr was 32 of 48 for 268 yards, and Davante Adams had 11 receptions for 86 yards.
In the first half, Rashad Evans caught a 6-yard touchdown pass and returned a punt 78 yards for a score as the Bulldogs built a 35-0 lead at intermission.