Enders ran 52 yards for a touchdown with just over three minutes left in the game to seal the victory.
Maine scored with 38 seconds remaining in the game to close the spread to five points, but the Black Bears failed on the two-point conversion try, and Towson recovered the onside kick.
Enders finished 17 of 26 with 260 yards passing and 98 yards rushing on eight carries for the Tigers (3-3, 2-1). He also threw an interception that was returned 92 yards for a touchdown by Maine’s Troy Eastman.
Towson’s Terrance West ran for 96 yards and a touchdown.
Maine (2-4, 1-2) was led by Marcus Wasilewski, who passed for 159 yards and rushed for 60 yards and a touchdown.