Piatkowski was 21 of 31 passing for 250 yards and four touchdowns, including two to Nick Rosa who finished the game with 112 yards on six catches. Kevin Marshall caught a 5-yard pass and scored his first touchdown of the season. Piatkowski also ran the ball 8 yards for a touchdown.
Mason Mills was 24 of 37 for 216 passing yards. San Diego (2-3, 1-1)) got on the scoreboard in the second quarter as Brandon White caught a 2-yard pass from Mills for a touchdown. Ernie Collins added a field goal in the fourth.
Along with the win, Drake celebrated homecoming.