The Bulldogs (6-2, 4-1 Pioneer League) scored touchdowns on their first five possessions and returned an interception for another score en route to a 42-0 lead in the second quarter.
Piatkowski completed 16 of 23 passes. Trey Morse rushed for 60 yards and a touchdown on 17 carries.
Valparaiso (0-7, 0-4) was limited to 125 yards of offense.
That was the first of three consecutive first-quarter Crusaders drives that ended with a turnover. Drake did not need to drive far—27 and 42 yards, respectively—to cash in the other two takeaways.