Royce O’Neale added 11 points for the Pioneers (17-8, 13-2 Western Athletic), who have won six straight games and 13 of 14.
With eight points—all in the final five minutes—LaVanne Pennington was the top scorer for the Spartans (9-16, 3-11), who lost their 10th in a row. Chris Cunningham had 12 rebounds.
Denver used a 13-1 run to take control of the game with a 28-12 advantage with 2:20 remaining before halftime.
San Jose State, which trailed 28-14 at intermission, got no closer than 12 points in the second half.
The Pioneers shot 53.3 percent (24 of 45) from the floor.