Eric Stutz had 12 points and Corey Walden added 11, helping Eastern Kentucky (19-6, 8-3) win its third straight game.
Morehead State (11-14, 5-6) shot just 21.7 percent (5 of 23) in the first half and trailed at halftime 30-20.
The Colonels shot 60.9 percent (14 of 23) in the second half to extend their lead, and led by as many 24 points.
Eastern Kentucky outscored the Eagles 38-10 in the paint and had a 24-4 advantage on points off turnovers.
No player had over four rebounds for Morehead State, as the Colonels were outrebounded 32-24.
Angelo Warner scored 16 points and Bakari Turner was the only other player for Morehead State in double figures with 10.