Juvonte Reddic went 9 of 12 from the field, finishing with 20 points for VCU (9-3).
Treveon Graham and Rob Brandenburg made three 3-pointers apiece, scoring 16 and 11 points, respectively, for the Rams.
VCU started the game on a 19-8 run. Reddic and Graham scored all 19 points, with Graham going 3 for 3 from 3-point range during the run. VCU led at halftime 50-31.
Longwood (3-10) shot just 38.5 percent (10 for 26) in the second half as VCU extended the lead.
VCU turned the ball over 12 times compared to 27 turnovers for the Lancers.
The Rams shot 50 percent from deep, making 14 of 28 3-pointers.
David Robinson led Longwood with 18 points, but turned the ball over seven times.