Kevin Foster had 12 points on four 3-pointers and Robert Garrett added nine points and 10 rebounds for the Broncos (6-2).
Will Bell scored 11 points for Pacific Union (0-7), an NAIA school in Angwin, Calif.
Santa Clara enjoyed a 42-25 rebounding advantage and outscored the Pioneers 44-10 in the paint.
The Broncos led 44-17 at halftime.
- Santa Clara defeats Pacific Union 77-42
- Iowa State suspends Jameel McKay for violating team rules
- Macura's 20 points lead No. 6 Xavier over Marquette 90-82
- Ellis has double-double for No. 7 Kansas in 75-56 win at TCU
- Garino scores 27 as George Washington beats VCU, 72-69
- Brey: Notre Dame not intimidated by No. 2 North Carolina