Ian Chiles led seventh-seeded IUPUI (14-18) with 15 points. Sean Esposito added 11 and Alex Young and Stephen Thomas each had 10.
South Dakota State, which beat the Jaguars for the third time this season, also got 12 points from Brayden Carlson, 11 from Tony Fiegen and 10 from Taevaunn Prince.
The Jackrabbits never trailed in the game, jumping out to an early 13-4 lead and a 40-28 halftime advantage. The lead remained in double digits throughout the second half.