The Jaspers (18-10, 11-5 Metro Atlantic Athletic Conference) suffered their third loss in four games after an eight-game winning streak, including 72-53 over the Saints on Jan. 14.
Siena (12-14, 7-9), meanwhile, moved a half-game ahead of Niagara in the MAAC race for sixth place—which carries a first-round tournament bye.
Hymes was 8 of 13 from the field, hitting 5 of 7 from long range, Kyle Downey added 18 points on 7-of-10 shooting and OD Anosike scored 14.
The Saints, who led 33-27 at intermission, opened the second half with 19 straight free throws. They finished 22 of 24 from the line after the break to maintain a five-point cushion.
George Beamon’s 16 points led Manhattan, which lost starting point guard Michael Alvarado to a first-half injury.
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