Caldwell-Pope, a freshman, hit four 3-pointers, and Gerald Robinson scored 17 points for Georgia (5-5), which snapped a four-game losing skid.
The Bulldogs, one of worst-shooting teams in the nation, shot a season-high 51 percent. They made 9 of 13 3-pointers.
Alexis Moore scored 18 points to lead USC (4-7), while Maurice Jones had 11. Aaron Fuller added 10 points.
Caldwell-Pope made a 3-pointer to put Georgia up 60-56 with 43 seconds left. He later added a pair of insurance free throws.