Devon Collier added 25 points, also a career best, for the Beavers, who are 3-0 for the first time in 11 years.
Oregon State outscored Hofstra 12-4 in the first 2:24 of the second half to go ahead 51-45 and never trailed again. Hofstra got within two points twice before the Beavers pulled away in the final six minutes.
Cunningham made 11 of 15 shots from the field, including a 3-pointer, and went 12 for 17 from the free-throw line.
Joe Burton added five points, 10 rebounds and a career-high 11 assists for Oregon State. Mike Moore scored 16 points and David Imes added 15 for Hofstra (1-1).