The 76ers are just two games behind the Pistons in the Eastern Conference standings after going a league-best 15-2 after the All-Star break.
Philadelphia - which moved percentage points ahead of New Jersey for the Atlantic Division lead after the Nets lost on Wednesday - won its fourth straight game on Tuesday, 103-83 at Miami, to improve to 2-0 on its trip.
The Pistons have won five of six contests after dropping a season-high seven straight.
On Tuesday, Detroit edged Washington on the road in overtime, 94-90.
Ben Wallace contributed 20 rebounds and seven blocks for Detroit. Wallace has pulled down at least 20 rebounds in his last four games.
The teams split their first two games this season, with Philadelphia winning here on January 22, 92-83. The Sixers have won three of four at The Palace.