The Bucks, who are meeting the Spurs for the first time this season, swept the previous three season series. San Antonio last defeated Milwaukee on March 18, 1998, posting a 96-85 victory here.
Milwaukee has won its last two contests, including a 138-133 overtime triumph over Golden State on Saturday.
The Bucks, who had six players scored at least 17 points, erased a 16-point deficit in the final 9 1/2 minutes of regulation.
Milwaukee is in eighth place in the Eastern Conference, one-half game behind Orlando and two games ahead of Washington.
San Antonio has won back-to-back games, six of seven and 15 of 17. On Sunday, the Spurs opened a three-game road trip with a 94-78 victory over Boston.
San Antonio is 24-5 since the beginning of the year.