Pierce has missed the Celtics’ last two games, both against Toronto, because of a strained lower back suffered while slipping on ice last week.
On Sunday, Boston lost at Toronto, 104-92. Antoine Walker scored a season-high 38 points but was ejected after picking up two technicals down the stretch.
Memphis hast lost four of its last six games, including a 114-87 blowout defeat at Dallas on Saturday.
The Celtics have won three in a row over the Grizzlies, including a 96-89 victory at home on December 31.