The Spurs defeated Indiana on Saturday, 105-96, for their third straight home win since a loss to Memphis on January 22.
The Spurs are 9-0 at home against teams from the Eastern Conference and have won 12 of their last 13 at the SBC Center.
Miami, which is opening a three-game road trip, snapped a three-game losing streak with a 100-90 home triumph over Chicago on Saturday.
Rookie Caron Butler sat out the game because of severe flu-like symptoms. He spent two nights in a hospital in nearby Coral Gables and will miss this contest and the Heat’s game at New Orleans on Wednesday in order to recuperate from dehydration. He may join the team for Friday’s game at Memphis.
Fellow rookie Rasual Butler is expect to start in his place.
The Spurs edged the Heat in Miami on February 1, 67-65. San Antonio has won three in a row and 14 of 15 all time at home against the Heat.