The Rockets have lost five of their last seven home games, including three straight, after opening the season 17-5 at the Compaq Center. They are trying to avoid falling to one-game over .500 for the first time since November 26.
Houston has dropped six of its last eight overall games, including a 100-85 home loss to the Dallas Mavericks on Friday.
Houston is 3-11 in the first night of back-to-back games this season but is 9-4 in the finales.
Memphis has won three of five following a seven-game slide, but comes off a 125-123 overtime road loss to the New Orleans Hornets on Friday.
The Grizzlies and Rockets have split two meetings at The Pyramid this season. Memphis has won three of the last four meetings with Houston, including 114-109 overtime victory on December 13.
The Rockets have a 21-7 lead in the all-time series, including a 12-2 advantage at home.