The Clippers, who are in last place in the Pacific Division, have lost back-to-back contests and five of seven.
Los Angeles fell to 1-3 on its five-game road trip with Sunday’s 108-101 set back at Eastern Conference-leading Indiana, 108-101.
Clippers guard Andre Miller returns to Cleveland for the first time since he was traded to Los Angeles in July. Miller was drafted in the first round of the NBA Draft by the Cavaliers in 1999.
The Cavaliers have struggled all season and have dropped six straight games and nine of 10.
On Saturday, Cleveland lost to Atlanta here in overtime, 102-101. Zydrunas Ilgauskas scored 19 points and rookie Smush Parker added 17 but they could not prevent interim coach Keith Smart from falling to 0-2.
The Cavs are on their longest skid since losing 15 straight from November 6-December 2. They also lost five in a row at home since a 74-72 victory over Miami on December 23.
Cleveland defeated Los Angeles on the road on October 30, 98-96, to snap a four-game losing streak in the series. The Clippers have won two in a row in Cleveland but the Cavs have won 18 of the last 22 matchups here.