The Magic have not lost at home to the Bulls since an 85-70 setback on March 25, 1998.
Orlando had won six straight and 13 of 14 overall against the Bulls before a 107-87 defeat at Chicago on December 10.
The Magic beat Cleveland on the road on Tuesday, 103-94.
Tracy McGrady, the league’s leading scorer, contributed 35 points and Pat Garrity added 20 as Orlando spoiled Keith Smart’s NBA coaching debut. Mike Miller sat out his second straight game for Orlando with an ankle injury.
Chicago snapped a 19-game road losing streak on Monday with a 115-102 triumph at Atlanta.
Jalen Rose scored a season high-tying 37 points for the Bulls, who improved to 1-3 on their five-game road trip and notched their first victory away from the United Center since a win over Boston on October 30.
The Bulls have not won consecutive road games since winning three in a row from April 10-15 of last season.