Seattle Mariners
- 20-27,
- 4th AL West
| Date | Opponent | Result | Win | Loss | Save |
|---|---|---|---|---|---|
| Tue, May 1 | Tampa Bay Rays @ Tampa Bay (15-8) | L 1 - 3 | M. Moore | H. Noesi | F. Rodney |
| Wed, May 2 | Tampa Bay Rays @ Tampa Bay (16-8) | L 4 - 5 | J. Shields | B. Beavan | J. Peralta |
| Thu, May 3 | Tampa Bay Rays @ Tampa Bay (17-8) | L 3 - 4 | J. Niemann | K. Millwood | F. Rodney |
| Fri, May 4 | Minnesota Twins vs Minnesota (6-18) | L 2 - 3 | C. Pavano | T. Wilhelmsen | M. Capps |
| Sat, May 5 | Minnesota Twins vs Minnesota (7-18) | W 7 - 0 | F. Hernandez | J. Marquis | |
| Sun, May 6 | Minnesota Twins vs Minnesota (7-19) | W 5 - 2 | H. Noesi | N. Blackburn | |
| Mon, May 7 | Detroit Tigers vs Detroit (14-13) | W 3 - 2 | S. Delabar | O. Dotel | |
| Tue, May 8 | Detroit Tigers vs Detroit (14-14) | L 4 - 6 | J. Verlander | K. Millwood | J. Valverde |
| Wed, May 9 | Detroit Tigers vs Detroit (15-14) | W 2 - 1 | J. Vargas | L. Putkonen | B. League |
| Fri, May 11 | New York Yankees @ NY Yankees (17-14) | L 2 - 6 | H. Kuroda | F. Hernandez | |
| Sat, May 12 | New York Yankees @ NY Yankees (18-14) | L 2 - 6 | P. Hughes | H. Noesi | B. Logan |
| Sun, May 13 | New York Yankees @ NY Yankees (19-14) | W 6 - 2 | K. Millwood | A. Pettitte | |
| Mon, May 14 | Boston Red Sox @ Boston (15-19) | L 1 - 6 | J. Lester | J. Vargas | |
| Tue, May 15 | Boston Red Sox @ Boston (16-19) | L 0 - 5 | J. Beckett | B. Beavan | |
| Wed, May 16 | Cleveland Indians @ Cleveland (20-16) | L 3 - 9 | U. Jimenez | F. Hernandez | |
| Thu, May 17 | Cleveland Indians @ Cleveland (21-16) | L 5 - 6 | J. Smith | B. League | |
| Fri, May 18 | Colorado Rockies @ Colorado (15-22) | W 4 - 0 | K. Millwood | A. White | |
| Sat, May 19 | Colorado Rockies @ Colorado (15-23) | W 10 - 3 | J. Vargas | C. Friedrich | |
| Sun, May 20 | Colorado Rockies @ Colorado (15-24) | W 6 - 4 | B. Beavan | J. Guthrie | |
| Mon, May 21 | Texas Rangers vs Texas (26-16) | W 6 - 1 | F. Hernandez | Y. Darvish | |
| Tue, May 22 | Texas Rangers vs Texas (26-17) | L 1 - 3 | M. Harrison | H. Noesi | J. Nathan |
| Wed, May 23 | Texas Rangers vs Texas (27-17) | W 5 - 3 | K. Millwood | S. Feldman | B. League |
| Thu, May 24 | Los Angeles Angels vs LA Angels (20-25) | L 0 - 3 | D. Haren | J. Vargas | |
| Fri, May 25 | Los Angeles Angels vs LA Angels (21-25) | L 4 - 6 | J. Isringhausen | B. League | S. Downs |
| Sat, May 26 | Los Angeles Angels vs LA Angels (22-25) | L 3 - 5 | J. Williams | F. Hernandez | E. Frieri |
| Sun, May 27 | Los Angeles Angels vs LA Angels (23-25) | L 2 - 4 | C. Wilson | H. Noesi | S. Downs |
| Mon, May 28 | Texas Rangers @ Texas (30-18) | L 2 - 4 | M. Harrison | S. Delabar | J. Nathan |
| Tue, May 29 | Texas Rangers @ Texas (31-18) | W 10 - 3 | J. Vargas | S. Feldman | |
| Wed, May 30 | Texas Rangers @ Texas (31-19) | W 21 - 8 | B. Beavan | D. Holland | H. Iwakuma |
* if needed