Pittsburgh Pirates
- 25-17,
- 3rd NL Central
| Date | Opponent | Result | Win | Loss | Save |
|---|---|---|---|---|---|
| Sat, Sep 1 | Milwaukee Brewers @ Milwaukee (63-68) | L 2 - 3 | J. Axford | J. Hanrahan | |
| Sun, Sep 2 | Milwaukee Brewers @ Milwaukee (64-68) | L 8 - 12 | K. Loe | J. McDonald | J. Axford |
| Mon, Sep 3 | Houston Astros vs Houston (41-93) | L 1 - 5 | E. Gonzalez | J. Locke | |
| Tue, Sep 4 | Houston Astros vs Houston (42-93) | W 6 - 2 | W. Rodriguez | J. Lyles | |
| Wed, Sep 5 | Houston Astros vs Houston (42-94) | W 6 - 3 | K. Correia | F. Abad | |
| Fri, Sep 7 | Chicago Cubs vs Chi Cubs (51-86) | L 2 - 12 | T. Wood | A. Burnett | |
| Sat, Sep 8 | Chicago Cubs vs Chi Cubs (52-86) | L 3 - 4 | J. Samardzija | J. Grilli | |
| Sun, Sep 9 | Chicago Cubs vs Chi Cubs (53-86) | L 2 - 4 | J. Russell | J. Grilli | C. Marmol |
| Mon, Sep 10 | Cincinnati Reds @ Cincinnati (84-57) | L 3 - 4 | A. Simon | R. van den Hurk | |
| Tue, Sep 11 | Cincinnati Reds @ Cincinnati (85-57) | L 3 - 5 | M. Leake | K. Correia | J. Broxton |
| Wed, Sep 12 | Cincinnati Reds @ Cincinnati (86-57) | L 1 - 2 | H. Bailey | A. Burnett | J. Hoover |
| Fri, Sep 14 | Chicago Cubs @ Chi Cubs (56-87) | L 4 - 7 | C. Rusin | J. McDonald | C. Marmol |
| Sat, Sep 15 | Chicago Cubs @ Chi Cubs (57-87) | W 7 - 6 | W. Rodriguez | J. Berken | J. Hanrahan |
| Sun, Sep 16 | Chicago Cubs @ Chi Cubs (57-88) | L 9 - 13 | J. Beliveau | J. Hughes | |
| Mon, Sep 17 | Chicago Cubs @ Chi Cubs (58-88) | W 3 - 0 | K. Correia | T. Wood | J. Hanrahan |
| Tue, Sep 18 | Milwaukee Brewers vs Milwaukee (74-72) | L 0 - 6 | Y. Gallardo | A. Burnett | |
| Wed, Sep 19 | Milwaukee Brewers vs Milwaukee (75-72) | L 1 - 3 | M. Estrada | K. McPherson | J. Axford |
| Thu, Sep 20 | Milwaukee Brewers vs Milwaukee (76-72) | L 7 - 9 | M. Parra | C. Resop | J. Axford |
| Fri, Sep 21 | Houston Astros @ Houston (48-102) | L 1 - 7 | F. Rodriguez | J. Locke | |
| Sat, Sep 22 | Houston Astros @ Houston (49-102) | L 1 - 4 | D. Keuchel | K. Correia | W. Lopez |
| Sun, Sep 23 | Houston Astros @ Houston (50-102) | W 8 - 1 | A. Burnett | J. Lyles | |
| Mon, Sep 24 | New York Mets @ NY Mets (69-83) | L 2 - 6 | J. Mejia | K. McPherson | |
| Tue, Sep 25 | New York Mets @ NY Mets (70-83) | W 10 - 6 | W. Rodriguez | C. McHugh | |
| Wed, Sep 26 | New York Mets @ NY Mets (70-84) | L 0 - 6 | J. Hefner | J. Locke | |
| Thu, Sep 27 | New York Mets @ NY Mets (71-84) | L 5 - 6 | R. Dickey | K. Correia | B. Parnell |
| Fri, Sep 28 | Cincinnati Reds vs Cincinnati (94-62) | L 0 - 1 | H. Bailey | A. Burnett | |
| Sat, Sep 29 | Cincinnati Reds vs Cincinnati (95-62) | W 2 - 1 | J. Hanrahan | J. Broxton | |
| Sun, Sep 30 | Cincinnati Reds vs Cincinnati (95-63) | L 3 - 4 | S. Marshall | J. Hanrahan | A. Chapman |
* if needed