New York Yankees
- 27-16,
- 1st AL East
| Date | Opponent | Result | Win | Loss | Save |
|---|---|---|---|---|---|
| Sun, Apr 1 | Miami Marlins @ Miami (S) | W 10 - 8 | |||
| Mon, Apr 2 | Miami Marlins @ Miami (S) | W 5 - 2 | |||
| Tue, Apr 3 | New York Mets @ NY Mets (S) | L 6 - 7 | |||
| Wed, Apr 4 | New York Mets vs NY Mets (S) | W 8 - 3 | |||
| Fri, Apr 6 | Tampa Bay Rays @ Tampa Bay (0-0) | L 6 - 7 | F. Rodney | M. Rivera | |
| Sat, Apr 7 | Tampa Bay Rays @ Tampa Bay (1-0) | L 6 - 8 | D. Price | H. Kuroda | F. Rodney |
| Sun, Apr 8 | Tampa Bay Rays @ Tampa Bay (2-0) | L 0 - 3 | J. Hellickson | P. Hughes | F. Rodney |
| Mon, Apr 9 | Baltimore Orioles @ Baltimore (3-0) | W 6 - 2 | I. Nova | B. Matusz | |
| Tue, Apr 10 | Baltimore Orioles @ Baltimore (3-1) | W 5 - 4 | C. Rapada | P. Strop | M. Rivera |
| Wed, Apr 11 | Baltimore Orioles @ Baltimore (3-2) | W 6 - 4 | R. Soriano | K. Gregg | M. Rivera |
| Fri, Apr 13 | Los Angeles Angels vs LA Angels (2-4) | W 5 - 0 | H. Kuroda | E. Santana | |
| Sat, Apr 14 | Los Angeles Angels vs LA Angels (2-5) | L 1 - 7 | C. Wilson | P. Hughes | |
| Sun, Apr 15 | Los Angeles Angels vs LA Angels (3-5) | W 11 - 5 | I. Nova | J. Williams | |
| Mon, Apr 16 | Minnesota Twins vs Minnesota (2-7) | L 3 - 7 | C. Pavano | F. García | |
| Tue, Apr 17 | Minnesota Twins vs Minnesota (3-7) | W 8 - 3 | C. Sabathia | F. Liriano | |
| Wed, Apr 18 | Minnesota Twins vs Minnesota (3-8) | L 5 - 6 | J. Marquis | H. Kuroda | M. Capps |
| Thu, Apr 19 | Minnesota Twins vs Minnesota (4-8) | W 7 - 6 | P. Hughes | A. Swarzak | M. Rivera |
| Fri, Apr 20 | Boston Red Sox @ Boston (4-8) | W 6 - 2 | I. Nova | C. Buchholz | |
| Sat, Apr 21 | Boston Red Sox @ Boston (4-9) | W 15 - 9 | R. Soriano | A. Aceves | |
| Sun, Apr 22 | Boston Red Sox @ Boston | Postponed | |||
| Mon, Apr 23 | Texas Rangers @ Texas (13-3) | W 7 - 4 | C. Sabathia | D. Holland | M. Rivera |
| Tue, Apr 24 | Texas Rangers @ Texas (13-4) | L 0 - 2 | Y. Darvish | H. Kuroda | J. Nathan |
| Wed, Apr 25 | Texas Rangers @ Texas (14-4) | L 3 - 7 | R. Ross | P. Hughes | |
| Fri, Apr 27 | Detroit Tigers vs Detroit (10-9) | W 7 - 6 | M. Rivera | B. Villarreal | |
| Sat, Apr 28 | Detroit Tigers vs Detroit (10-10) | L 5 - 7 | D. Smyly | F. García | |
| Sun, Apr 29 | Detroit Tigers vs Detroit (11-10) | W 6 - 2 | C. Sabathia | M. Scherzer | |
| Mon, Apr 30 | Baltimore Orioles vs Baltimore (14-8) | W 2 - 1 | H. Kuroda | J. Hammel | M. Rivera |
* if needed