Houston Astros
- 14-33,
- 5th AL West
| Date | Opponent | Result | Win | Loss | Save |
|---|---|---|---|---|---|
| Fri, Jun 1 | Cincinnati Reds vs Cincinnati (28-22) | L 1 - 4 | M. Leake | J. Happ | A. Chapman |
| Sat, Jun 2 | Cincinnati Reds vs Cincinnati (29-22) | L 9 - 12 | S. LeCure | F. Rodriguez | A. Chapman |
| Sun, Jun 3 | Cincinnati Reds vs Cincinnati (30-22) | W 5 - 3 | J. Lyles | B. Arroyo | B. Myers |
| Tue, Jun 5 | St. Louis Cardinals vs St. Louis (28-27) | W 9 - 8 | L. Harrell | J. Garcia | B. Myers |
| Wed, Jun 6 | St. Louis Cardinals vs St. Louis (28-28) | L 3 - 4 | A. Wainwright | B. Norris | J. Motte |
| Thu, Jun 7 | St. Louis Cardinals vs St. Louis (29-28) | L 2 - 14 | L. Lynn | J. Happ | |
| Fri, Jun 8 | Chicago White Sox @ Chi White Sox (32-25) | W 8 - 3 | W. Rodriguez | G. Floyd | |
| Sat, Jun 9 | Chicago White Sox @ Chi White Sox (32-26) | L 1 - 10 | C. Sale | J. Lyles | |
| Sun, Jun 10 | Chicago White Sox @ Chi White Sox (33-26) | W 11 - 9 | L. Harrell | P. Humber | B. Myers |
| Tue, Jun 12 | San Francisco Giants @ San Francisco (34-27) | L 3 - 6 | M. Bumgarner | B. Norris | S. Casilla |
| Wed, Jun 13 | San Francisco Giants @ San Francisco (35-27) | L 0 - 10 | M. Cain | J. Happ | |
| Thu, Jun 14 | San Francisco Giants @ San Francisco (36-27) | W 6 - 3 | W. Rodriguez | B. Zito | B. Myers |
| Fri, Jun 15 | Texas Rangers @ Texas (37-27) | L 2 - 6 | Y. Darvish | J. Lyles | |
| Sat, Jun 16 | Texas Rangers @ Texas (38-27) | L 3 - 8 | J. Grimm | L. Harrell | |
| Sun, Jun 17 | Texas Rangers @ Texas (39-27) | L 3 - 9 | C. Lewis | F. Rodriguez | |
| Mon, Jun 18 | Kansas City Royals vs Kansas City (29-35) | W 9 - 7 | J. Happ | J. Sanchez | X. Cedeno |
| Tue, Jun 19 | Kansas City Royals vs Kansas City (29-36) | L 0 - 2 | L. Hochevar | W. Rodriguez | J. Broxton |
| Wed, Jun 20 | Kansas City Royals vs Kansas City (30-36) | L 1 - 2 | B. Chen | J. Lyles | J. Broxton |
| Fri, Jun 22 | Cleveland Indians vs Cleveland (36-32) | L 0 - 2 | U. Jimenez | L. Harrell | C. Perez |
| Sat, Jun 23 | Cleveland Indians vs Cleveland (37-32) | W 8 - 1 | D. Keuchel | J. Gomez | |
| Sun, Jun 24 | Cleveland Indians vs Cleveland (37-33) | W 7 - 1 | J. Happ | D. Lowe | |
| Mon, Jun 25 | San Diego Padres vs San Diego (26-47) | L 7 - 8 | D. Thayer | B. Lyon | H. Street |
| Tue, Jun 26 | San Diego Padres vs San Diego (27-47) | W 5 - 3 | J. Lyles | K. Wells | B. Myers |
| Wed, Jun 27 | San Diego Padres vs San Diego (27-48) | W 1 - 0 | L. Harrell | C. Richard | |
| Thu, Jun 28 | San Diego Padres vs San Diego (27-49) | L 3 - 7 | N. Vincent | B. Myers | |
| Fri, Jun 29 | Chicago Cubs @ Chi Cubs (26-49) | L 0 - 4 | P. Maholm | B. Norris | C. Marmol |
| Sat, Jun 30 | Chicago Cubs @ Chi Cubs (27-49) | L 2 - 3 | M. Garza | J. Happ | C. Marmol |
* if needed