Colorado Rockies
- 23-20,
- 3rd NL West
| Date | Opponent | Result | Win | Loss | Save |
|---|---|---|---|---|---|
| Tue, May 1 | Los Angeles Dodgers vs LA Dodgers (16-7) | L 6 - 7 | T. Lilly | J. Chacin | J. Guerra |
| Wed, May 2 | Los Angeles Dodgers vs LA Dodgers (17-7) | W 8 - 5 | R. Betancourt | J. Wright | |
| Fri, May 4 | Atlanta Braves vs Atlanta (15-11) | L 8 - 9 | C. Durbin | E. Escalona | C. Kimbrel |
| Sat, May 5 | Atlanta Braves vs Atlanta (16-11) | L 9 - 13 | C. Martínez | E. Rogers | L. Hernández |
| Sun, May 6 | Atlanta Braves vs Atlanta (17-11) | L 2 - 7 | B. Beachy | J. Nicasio | C. Martínez |
| Mon, May 7 | San Diego Padres @ San Diego (9-20) | L 2 - 3 | E. Vólquez | D. Pomeranz | D. Thayer |
| Tue, May 8 | San Diego Padres @ San Diego (10-20) | L 1 - 3 | J. Suppan | A. White | D. Thayer |
| Wed, May 9 | San Diego Padres @ San Diego (11-20) | W 6 - 2 | C. Friedrich | A. Bass | |
| Fri, May 11 | Los Angeles Dodgers @ LA Dodgers (20-11) | L 3 - 7 | C. Capuano | J. Moyer | |
| Sat, May 12 | Los Angeles Dodgers @ LA Dodgers (21-11) | L 1 - 2 | A. Harang | J. Outman | K. Jansen |
| Sun, May 13 | Los Angeles Dodgers @ LA Dodgers (22-11) | L 5 - 11 | T. Lilly | A. White | |
| Mon, May 14 | San Francisco Giants @ San Francisco (17-17) | L 2 - 3 | S. Romo | R. Brothers | S. Casilla |
| Tue, May 15 | San Francisco Giants @ San Francisco (18-17) | W 5 - 4 | R. Brothers | S. Casilla | R. Betancourt |
| Wed, May 16 | Arizona Diamondbacks vs Arizona (16-21) | W 6 - 1 | J. Moyer | P. Corbin | |
| Thu, May 17 | Arizona Diamondbacks vs Arizona (16-22) | L 7 - 9 | B. Ziegler | R. Betancourt | J. Putz |
| Fri, May 18 | Seattle Mariners vs Seattle (16-24) | L 0 - 4 | K. Millwood | A. White | |
| Sat, May 19 | Seattle Mariners vs Seattle (17-24) | L 3 - 10 | J. Vargas | C. Friedrich | |
| Sun, May 20 | Seattle Mariners vs Seattle (18-24) | L 4 - 6 | B. Beavan | J. Guthrie | |
| Mon, May 21 | Miami Marlins @ Miami (22-19) | L 4 - 7 | M. Buehrle | J. Moyer | H. Bell |
| Tue, May 22 | Miami Marlins @ Miami (23-19) | L 6 - 7 | R. Nolasco | J. Nicasio | H. Bell |
| Wed, May 23 | Miami Marlins @ Miami (24-19) | W 8 - 4 | A. White | C. Zambrano | |
| Fri, May 25 | Cincinnati Reds @ Cincinnati (25-19) | W 6 - 3 | C. Friedrich | J. Cueto | R. Betancourt |
| Sat, May 26 | Cincinnati Reds @ Cincinnati (25-20) | L 3 - 10 | J. Hoover | J. Guthrie | |
| Sun, May 27 | Cincinnati Reds @ Cincinnati (26-20) | L 5 - 7 | M. Latos | J. Moyer | A. Chapman |
| Mon, May 28 | Houston Astros vs Houston (22-25) | W 9 - 7 | M. Belisle | F. Rodríguez | R. Betancourt |
| Mon, May 28 | Houston Astros vs Houston (22-26) | W 7 - 6 | J. Roenicke | B. Myers | |
| Wed, May 30 | Houston Astros vs Houston (22-27) | W 13 - 5 | C. Friedrich | L. Harrell | |
| Thu, May 31 | Houston Astros vs Houston (22-28) | W 11 - 5 | J. Guthrie | B. Norris |
* if needed