Chicago Cubs
- 18-26,
- 4th NL Central
| Date | Opponent | Result | Win | Loss | Save |
|---|---|---|---|---|---|
| Wed, May 1 | San Diego Padres vs San Diego (10-16) | W 6 - 2 | S. Feldman | A. Cashner | |
| Thu, May 2 | San Diego Padres vs San Diego (10-17) | L 2 - 4 | J. Thatcher | T. Wood | H. Street |
| Fri, May 3 | Cincinnati Reds vs Cincinnati (15-14) | L 5 - 6 | M. Leake | C. Villanueva | J. Hoover |
| Sat, May 4 | Cincinnati Reds vs Cincinnati (16-14) | L 4 - 6 | L. Ondrusek | C. Mármol | A. Chapman |
| Sun, May 5 | Cincinnati Reds vs Cincinnati (17-14) | L 4 - 7 | M. Latos | E. Jackson | J. Hoover |
| Mon, May 6 | Texas Rangers vs Texas (20-11) | W 9 - 2 | S. Feldman | N. Tepesch | |
| Tue, May 7 | St. Louis Cardinals vs St. Louis (20-11) | W 2 - 1 | T. Wood | L. Lynn | K. Gregg |
| Wed, May 8 | St. Louis Cardinals vs St. Louis (20-12) | L 4 - 5 | S. Maness | M. Bowden | E. Mujica |
| Fri, May 10 | Washington Nationals @ Washington (19-15) | L 3 - 7 | R. Detwiler | J. Samardzija | |
| Sat, May 11 | Washington Nationals @ Washington (20-15) | W 8 - 2 | E. Jackson | S. Strasburg | |
| Sun, May 12 | Washington Nationals @ Washington (20-16) | W 2 - 1 | J. Russell | R. Soriano | K. Gregg |
| Mon, May 13 | Colorado Rockies vs Colorado (20-17) | W 9 - 1 | T. Wood | J. Nicasio | |
| Tue, May 14 | Colorado Rockies vs Colorado (20-18) | L 4 - 9 | J. Francis | C. Villanueva | |
| Wed, May 15 | Colorado Rockies vs Colorado (21-18) | W 6 - 3 | J. Samardzija | J. Garland | |
| Fri, May 17 | New York Mets vs NY Mets (15-23) | L 2 - 3 | M. Harvey | E. Jackson | B. Parnell |
| Sat, May 18 | New York Mets vs NY Mets (16-23) | W 8 - 2 | S. Feldman | J. Hefner | |
| Sun, May 19 | New York Mets vs NY Mets (16-24) | L 3 - 4 | S. Rice | K. Fujikawa | B. Parnell |
| Tue, May 21 | Pittsburgh Pirates @ Pittsburgh (26-18) | L 4 - 5 | W. Rodríguez | J. Russell | J. Grilli |
| Wed, May 22 | Pittsburgh Pirates @ Pittsburgh | 0 - 0 | |||
| Thu, May 23 | Pittsburgh Pirates @ Pittsburgh | 0 - 0 | |||
| Fri, May 24 | Cincinnati Reds @ Cincinnati | 0 - 0 | |||
| Sat, May 25 | Cincinnati Reds @ Cincinnati | 0 - 0 | |||
| Sun, May 26 | Cincinnati Reds @ Cincinnati | 0 - 0 | |||
| Mon, May 27 | Chicago White Sox @ Chi White Sox | 0 - 0 | |||
| Tue, May 28 | Chicago White Sox @ Chi White Sox | 0 - 0 | |||
| Wed, May 29 | Chicago White Sox vs Chi White Sox | 0 - 0 | |||
| Thu, May 30 | Chicago White Sox vs Chi White Sox | 0 - 0 | |||
| Fri, May 31 | Arizona Diamondbacks vs Arizona | 0 - 0 |
* if needed