| Pitching | G | GS | W | L | SV | BS | HLD | CG | SHO | IP | H | R | ER | HR | BB | K | ERA | WHIP | BAA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Totals | 174 | 72 | 70 | 19 | 73 | 188 | 3.43 | 1.34 | .248 | ||||||||||
| League Rank | 9 | 4 | 5 | T6 | T21 | 27 | 5 | 17 | 7 | ||||||||||
| Andrew Bailey | 4 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 3.1 | 1 | 0 | 0 | 0 | 1 | 5 | 0.00 | 0.60 | .091 |
| Craig Breslow | 3 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 3.2 | 2 | 0 | 0 | 0 | 1 | 1 | 0.00 | 0.82 | .167 |
| José De La Torre | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.00 | 0.00 | .000 |
| Clay Buchholz | 3 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 21.0 | 12 | 3 | 3 | 2 | 8 | 21 | 1.29 | 0.95 | .164 |
| Joel Hanrahan | 5 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 5.0 | 4 | 1 | 1 | 0 | 1 | 2 | 1.80 | 1.00 | .235 |
| Koji Uehara | 10 | 0 | 0 | 0 | 1 | 0 | 6 | 0 | 0 | 9.1 | 8 | 2 | 2 | 1 | 3 | 16 | 1.93 | 1.18 | .229 |
| Clayton Mortensen | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 12.1 | 11 | 3 | 3 | 1 | 8 | 10 | 2.19 | 1.54 | .244 |
| Andrew Miller | 10 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 8.0 | 6 | 2 | 2 | 0 | 4 | 12 | 2.25 | 1.25 | .207 |
| Álex Wilson | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 8.0 | 9 | 2 | 2 | 0 | 3 | 6 | 2.25 | 1.50 | .290 |
| Junichi Tazawa | 10 | 0 | 2 | 1 | 0 | 2 | 3 | 0 | 0 | 10.2 | 10 | 3 | 3 | 2 | 2 | 15 | 2.53 | 1.13 | .250 |
| Jon Lester | 6 | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 38.0 | 33 | 15 | 14 | 3 | 8 | 35 | 3.32 | 1.08 | .224 |
| John Lackey | 4 | 4 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 19.2 | 21 | 11 | 10 | 2 | 5 | 20 | 4.58 | 1.32 | .263 |
| Ryan Dempster | 3 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 15.2 | 17 | 9 | 9 | 2 | 13 | 14 | 5.17 | 1.91 | .279 |
| Felix Doubront | 4 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 18.2 | 28 | 13 | 13 | 2 | 11 | 22 | 6.27 | 2.09 | .354 |
| Alfredo Aceves | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 9.1 | 12 | 8 | 8 | 4 | 5 | 7 | 7.71 | 1.82 | .308 |